Document 0542
 DOCN  M9480542
 TI    Serum and cerebrospinal fluid levels of soluble intercellular adhesion
       molecule 1 (sICAM-1) in patients with HIV-1 associated neurological
       diseases.
 DT    9410
 AU    Heidenreich F; Arendt G; Jander S; Jablonowski H; Stoll G; Department of
       Neurology, Heinrich-Heine Universitat,; Dusseldorf, Germany.
 SO    J Neuroimmunol. 1994 Jul;52(2):117-26. Unique Identifier : AIDSLINE
       MED/94308290
 AB    We measured levels of soluble intercellular adhesion molecule 1
       (sICAM-1) in paired serum and CSF samples of 110 HIV-1-positive patients
       with and without neurological symptoms and 40 HIV-negative non-immune
       neurological controls, and in sera of 26 asymptomatic HIV-1-positive
       patients. Serum sICAM-1 levels in asymptomatic HIV-1-positive patients
       were significantly increased in comparison to HIV-negative controls.
       Moreover, they were significantly higher in HIV-1-positive patients with
       AIDS-defining diseases than in the asymptomatic HIV-1-positive group. In
       subgroups of patients with neurological disease, the highest serum
       values were found in HIV encephalopathy. CSF levels of sICAM-1 were
       elevated only in HIV-1-positive patients with neurological disease
       mainly due to passive diffusion through a defective blood-brain barrier.
       An sICAM-1 index was calculated as a measure for intrathecal production
       of sICAM-1 but showed no significant differences between patients with
       and without neurological involvement. However, increased levels of the
       sICAM-1 index were found in some patients with opportunistic CNS
       infection of bacterial or fungal origin. Serum and CSF levels of sICAM-1
       correlated with neopterin levels, a marker of interferon-gamma-mediated
       macrophage activation and CSF sICAM-1 levels were inversely correlated
       to numbers of CD4+ T cells. Elevated serum sICAM-1 levels already in
       asymptomatic HIV-1-positive individuals add to the evidence for an early
       immune activation in HIV infection. With the further increase of serum
       and CSF s-ICAM-1 in patients with AIDS-defining diseases sICAM-1 could
       serve as a new surrogate marker similar to neopterin.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/CEREBROSPINAL FLUID/
       *COMPLICATIONS  Antigens, CD/BLOOD/CEREBROSPINAL FLUID  AIDS Dementia
       Complex/BLOOD/CEREBROSPINAL FLUID  AIDS-Related Opportunistic
       Infections/BLOOD/CEREBROSPINAL FLUID  Cell Adhesion
       Molecules/*BLOOD/*CEREBROSPINAL FLUID  Comparative Study  Human  Nervous
       System Diseases/*ETIOLOGY/*METABOLISM  Solubility  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).